Hydrochloric Acid → HCID 70212260, 화합물

HRID 2269345노트

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HRID 2269345 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([NH:7][C:8](=[O:22])[C@@H:9]([NH:14]C(OC(C)(C)C)=O)[C:10]([CH3:13])([CH3:12])[CH3:11])[CH:2]=1.[ClH:23]>ClCCl.O1CCOCC1>[ClH:23].[ClH:23].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([NH:7][C:8](=[O:22])[C@@H:9]([NH2:14])[C:10]([CH3:11])([CH3:12])[CH3:13])[CH:2]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 70212244HCID 70212244, 화합물

생성물 1

HCID 70212260HCID 70212260, 화합물수율 94%

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 312751,4-Dioxane용매

반응 조건

온도
25 °C

실험 절차

To a solution of (2S)-2-tert-butoxycarbonylamino-3,3-dimethylbutanoic acid 3-pyridylamide (1.6 g, 5.21 mmol) in dichloromethane (10 mL) cooled at 0° C. is added 4 M HCl in dioxane (10 mL). The resulting solution is allowed to warm to 25° C. and is stirred for 3 h. The reaction mixture is concentrated and the solid is filtered to provide (2S)-2-amino-3,3-dimethylbutanoic acid 3-pyridylamide dihydrochloride (1.40 g, 94% yield) as a white solid.

후처리

  1. concentrationThe reaction mixture is concentrated
  2. filtrationthe solid is filtered

출처 및 근거

ORD 기록
ord-a10bcdccca694dd88a9f6a3686a9bccc
출처 데이터셋
uspto-grants-2001_12
특허 번호
US06329400B1

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