Sodium borohydride → 3-{(3,4-Dimethylphenyl)-[(S)-1-phenylethylamino]methyl}phenylamine

HRID 2269392노트

반응식

HRID 2269392 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]([C:20]2[CH:25]=[CH:24][C:23]([CH3:26])=[C:22]([CH3:27])[CH:21]=2)[NH:11][C@H:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH3:13])[CH:7]=[CH:8][CH:9]=1)([O-])=O.[BH4-].[Na+]>CO.O.O.O.O.O.O.[Ni](Cl)Cl>[CH3:27][C:22]1[CH:21]=[C:20]([CH:10]([NH:11][C@H:12]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH3:13])[C:6]2[CH:5]=[C:4]([NH2:1])[CH:9]=[CH:8][CH:7]=2)[CH:25]=[CH:24][C:23]=1[CH3:26]

참가 물질

5

반응물 2

HCID 4311764Sodium borohydrideHCID 70189822HCID 70189822, 화합물

생성물 1

HCID 701893313-{(3,4-Dimethylphenyl)-[(S)-1-phenylethylamino]methyl}phenylamine수율 77.8%

시약·촉매·용매 2

HCID 11791229Dichloronickel;hexahydrate촉매HCID 887Methanol용매

실험 절차

In a similar manner to that described in Example (1b), a solution of isomer B of N-[(3-nitrophenyl)-(3,4-dimethylphenyl)methyl]-N-[(S)-1-phenylethyl]amine (1.19 g) in methanol (20 ml), nickel chloride hexahydrate (1.57 g) and sodium borohydride (500 mg) were reacted, to afford isomer B of the title compound (849 mg) as a colorless oil.

출처 및 근거

ORD 기록
ord-2ae26db1f7fc4b028668ffe3061ca709
출처 데이터셋
uspto-grants-2001_12
특허 번호
US06329405B1

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