Phenol → HCID 18347201, 화합물

HRID 2269565노트

반응식

HRID 2269565 반응식
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[CH2:9][C:10]([C:12]1[CH:17]=[CH:16][C:15]([S:18][CH3:19])=[CH:14][CH:13]=1)=[O:11].C([O-])([O-])=O.[K+].[K+]>CC(C)=O.CCCCCC.CCOC(C)=O>[O:7]([CH2:9][C:10]([C:12]1[CH:17]=[CH:16][C:15]([S:18][CH3:19])=[CH:14][CH:13]=1)=[O:11])[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

6

반응물 3

HCID 996PhenolHCID 11430Potassium CarbonateHCID 27375232-Bromo-1-(4-methylsulfanylphenyl)ethanone

생성물 1

HCID 18347201HCID 18347201, 화합물

시약·촉매·용매 2

HCID 180Acetone용매HCID 21226206Ethyl acetate hexane용매

실험 절차

To a solution of phenol (9.4 g) and 2-bromo-1-(4-(methylthio)phenyl)ethanone (12.5 g) in 500 mL of acetone was added K2CO3 (13.8 g). The mixture was refluxed for 12 h, then diluted with 500 mL of 1:1 hexane/EtOAc. The solid was removed by filtration and the filtrate was concentrated. The residue was dissolved in Et2O (500 mL), washed with 1N NaOH (100 ml) and dried over MgSO4. After filtration and concentration, the title compound (9 g) was collected by filtration and air dried.

후처리

  1. temperatureThe mixture was refluxed for 12 h
  2. customThe solid was removed by filtration
  3. concentrationthe filtrate was concentrated
  4. dissolutionThe residue was dissolved in Et2O (500 mL)
  5. washwashed with 1N NaOH (100 ml)
  6. dry with materialdried over MgSO4
  7. filtrationAfter filtration and concentration
  8. filtrationthe title compound (9 g) was collected by filtration and air
  9. customdried

출처 및 근거

ORD 기록
ord-751651874417468293329595a7611527
출처 데이터셋
uspto-grants-2001_12
특허 번호
US06329421B1

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