홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Tert-Butylamine → Boc-Thz-NH-tBu

HRID 2269632
노트
인쇄 미리보기

반응식

HRID 2269632 반응식
[C:1]([O:5][C:6]([N:8]1[CH:12]([C:13]([OH:15])=O)[CH2:11][S:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:16]([NH2:20])([CH3:19])([CH3:18])[CH3:17].C1C=CC2N(O)N=NC=2C=1.CCN=C=NCCCN(C)C.Cl>CN(C=O)C>[N:8]1([C:6]([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:7])[CH2:9][S:10][CH2:11][C@H:12]1[C:13]([NH:20][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:15]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 6385Tert-ButylamineHCID 757711-HydroxybenzotriazoleHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 51470143-(1,1-Dimethylethyl) 3,4-thiazolidinedicarboxylate

생성물 1

HCID 54130109Boc-Thz-NH-tBu

시약·촉매·용매 1

HCID 6228
이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트
Dimethylformamide
용매

실험 절차

In a DMF solution containing 0.10 g of N-(t-butoxy-carbonyl)-1,3-thiazolidine-4-carboxylic acid, 45 μl of tert-butylamine, 66 mg of HOBt and 98 mg of EDC hydrochloride were added under ice cooling and the resultant mixture was stirred for 14 hr. The reaction mixture was treated similarly to that in Example 34 (Process 3) to give 90 mg of the title compound.

후처리

  1. additionwere added under ice cooling
  2. additionThe reaction mixture was treated similarly to that in Example 34 (Process 3)

출처 및 근거

ORD 기록
ord-0de970e6ce984da59722c8e010071989
출처 데이터셋
uspto-grants-2001_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06329502B1

반응 노트

불러오는 중…