Potassium Carbonate → 3-[4-(2-Benzofuranyl)thiazol-2-yl]propionic acid

HRID 2269708노트

반응식

HRID 2269708 반응식
[OH-].[Na+].[O:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[CH:5]=[C:4]1[C:12]1[N:13]=[C:14]([CH2:17][CH2:18][C:19]([O:21]CC)=[O:20])[S:15][CH:16]=1.C(=O)([O-])[O-].[K+].[K+]>CO>[O:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[CH:5]=[C:4]1[C:12]1[N:13]=[C:14]([CH2:17][CH2:18][C:19]([OH:21])=[O:20])[S:15][CH:16]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 14798Sodium HydroxideHCID 18333015Ethyl 3-[4-(2-benzofuranyl)thiazol-2-yl]propionate

생성물 1

HCID 183330873-[4-(2-Benzofuranyl)thiazol-2-yl]propionic acid수율 73.3%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

1N Sodium hydroxide (3 ml) was added dropwise to a methanol solution (3 ml) of ethyl 3-[4-(2-benzofuranyl)thiazol-2-yl]propionate (460 mg) under ice-cooling. The reaction mixture was stirred at room temperature overnight, to which was added 10% aqueous potassium carbonate solution (10 ml), and the mixture was washed with ethyl acetate. The aqueous layer was made acidic (pH 3) by adding 1N hydrochloric acid and extracted with ethyl acetate. The organic layer was dried and concentrated to obtain the entitled compound (306 mg).

후처리

  1. temperaturecooling
  2. washthe mixture was washed with ethyl acetate
  3. additionby adding 1N hydrochloric acid
  4. extractionextracted with ethyl acetate
  5. customThe organic layer was dried
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-6535890dff4a4e68984c103596038338
출처 데이터셋
uspto-grants-2001_12
특허 번호
US06329389B1

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