Phenol, 4-methoxy-2-nitro- → 2-Amino-4-methoxyphenol

HRID 22698

반응식

HRID 22698 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[C:5]([N+:10]([O-])=O)[CH:4]=1>CO.[Pd]>[NH2:10][C:5]1[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=[CH:7][C:6]=1[OH:9]

참가 물질

4

반응물 1

HCID 15285Phenol, 4-methoxy-2-nitro-

생성물 1

HCID 14191082-Amino-4-methoxyphenol

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of 4-methoxy-2-nitrophenol 11 (10 g, 59.1 mmol) and Pd/C (1.0 g) in methanol (100 ml) was placed on a Parr shaker under H2 (50 psi) for 60 minutes. The reaction mixture was filtered through Celite 521 and the filter cake washed with MeOH. The filtrate was evaporated (in vacuo), to yield compound 12 as a tan solid.

후처리

  1. filtrationThe reaction mixture was filtered through Celite 521
  2. washthe filter cake washed with MeOH
  3. customThe filtrate was evaporated (in vacuo)

출처 및 근거

ORD 기록
ord-4d5d8283e50c4141aca07510c1511933
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06849632B2

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