Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
m,alpha-Dichlorotoluene → 1-(3-Chloro-benzyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | m,alpha-Dichlorotoluene | HCID 12103 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylate | HCID 220876 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-(3-Chloro-benzyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester | HCID 57754723 | 87.6% |
반응 단계
Experimental conditions analogous to those described for Step 1 of Example 3, from 5.08 g (23.4 mmol) of 4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester, 1.12 g (28.1 mmol) of 60% sodium hydride, 4.52 g (28.1 mmol) of 3-chlorobenzyl chloride in 60 mL DMF at 60° C. to give 7.01 g of the product as an off-white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07557213B2 |
| 출처 데이터셋 | uspto-grants-2009_07 |
| ORD ID | ord-74ee13cff57c4ca38a0a25efa2422a70 |
| 출처 메모 | uspto-grants-2009_07 |