Benzoin acetate → Oxazole, 2-methyl-4,5-diphenyl-

HRID 2271231노트

반응식

HRID 2271231 반응식
[C:1]([O:4][CH:5]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:6](=O)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)(=O)[CH3:2].[NH2:20]C(N)=S>CN(C)C=O>[CH3:2][C:1]1[O:4][C:5]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:20]=1

참가 물질

4

반응물 2

HCID 95416Benzoin acetateHCID 2723790Thiourea

생성물 1

HCID 139703Oxazole, 2-methyl-4,5-diphenyl-

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
160 °C

실험 절차

0.2 g of the above 2-oxo-1,2-diphenylethyl acetate is dissolved in 10 ml of dimethylformamide in a reactor. 0.12 g of thiourea (2 eq.) is subsequently added and the reaction mixture is left to react at reflux (160° C.) for 10 hours. The reaction mixture is extracted using dichloromethane and then washed with water 3 times. The organic phase is recovered after separating by settling, dried over sodium sulphate, filtered and then concentrated to dryness under vacuum. The oil obtained is subsequently purified on a column of silica gel (elutent: dichloromethane).

후처리

  1. waitthe reaction mixture is left
  2. customto react
  3. extractionThe reaction mixture is extracted
  4. washwashed with water 3 times
  5. customThe organic phase is recovered
  6. customafter separating
  7. dry with materialdried over sodium sulphate
  8. filtrationfiltered
  9. concentrationconcentrated to dryness under vacuum
  10. customThe oil obtained
  11. customis subsequently purified on a column of silica gel (elutent: dichloromethane)

출처 및 근거

ORD 기록
ord-8a7688708a3646f9a5e5e5cbf2e407d1
출처 데이터셋
uspto-grants-2001_12
특허 번호
US06333414B1

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