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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride → 6-[3-(3,4-Dimethyl-benzoyl)-4-oxo-4H-quinolin-1-ylmethyl]-pyridine-2-carboxylic acid amide

HRID 227125
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인쇄 미리보기

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HRID 227125 반응식
Cl.[CH3:2][C:3]1[CH:4]=[C:5]([CH:29]=[CH:30][C:31]=1[CH3:32])[C:6]([C:8]1[C:17](=[O:18])[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]([CH2:19][C:20]2[N:25]=[C:24]([C:26](O)=[O:27])[CH:23]=[CH:22][CH:21]=2)[CH:9]=1)=[O:7].[Cl-].COC1N=C(OC)N=C([N+]2(C)CCOCC2)[N:37]=1>CS(C)=O.N>[CH3:2][C:3]1[CH:4]=[C:5]([CH:29]=[CH:30][C:31]=1[CH3:32])[C:6]([C:8]1[C:17](=[O:18])[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]([CH2:19][C:20]2[N:25]=[C:24]([C:26]([NH2:37])=[O:27])[CH:23]=[CH:22][CH:21]=2)[CH:9]=1)=[O:7]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 27340594-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chlorideHCID 668794056-[3-(3,4-dimethyl-benzoyl)-4-oxo-4H-quinolin-1-ylmethyl]-pyridine-2-carboxylic acid hydrochloride

생성물 1

HCID 577546416-[3-(3,4-Dimethyl-benzoyl)-4-oxo-4H-quinolin-1-ylmethyl]-pyridine-2-carboxylic acid amide수율 68.9%

시약·촉매·용매 2

HCID 222Ammonia용매
HCID 679
Dimethyl Sulfoxide
용매

실험 절차

27 mg (0.06 mmol) of 6-[3-(3,4-dimethyl-benzoyl)-4-oxo-4H-quinolin-1-ylmethyl]-pyridine-2-carboxylic acid hydrochloride was dissolved in a mixture of 2 mL DMSO and 0.2 mL 2 M methanolic ammonia followed by the addition of 100 mg (0.36 mmol) of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride. The mixture was stirred for 1 h at r.t. followed by purification on reverse-phase HPLC and flash chromatography to give 17 mg of a white solid. LC-MSD, m/z for C25H21N3O3 [M+H]+=412.2; HPLC retention time: 1.7 min.

후처리

  1. customfollowed by purification on reverse-phase HPLC and flash chromatography

출처 및 근거

ORD 기록
ord-750ed0afc44d4cd290cfc3a6c2ad67b4
출처 데이터셋
uspto-grants-2009_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07557213B2

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