p-Toluenesulfonic acid → Ethyl (3,4,6-Trifluoro-2-methylbenzoyl)acetate

HRID 2271271

반응식

HRID 2271271 반응식
[CH3:1][C:2]1[C:20]([F:21])=[C:19]([F:22])[CH:18]=[C:17]([F:23])[C:3]=1[C:4]([CH:6](C(OCC)=O)[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5].C1(C)C=CC(S(O)(=O)=O)=CC=1>O>[CH3:1][C:2]1[C:20]([F:21])=[C:19]([F:22])[CH:18]=[C:17]([F:23])[C:3]=1[C:4]([CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5]

참가 물질

4

반응물 2

HCID 6101p-Toluenesulfonic acidHCID 17879412Diethyl 2-methyl-3,4,6-trifluorobenzoylmalonate

생성물 1

HCID 14517129Ethyl (3,4,6-Trifluoro-2-methylbenzoyl)acetate수율 82.6%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To 5.1 g of diethyl 2-methyl-3,4,6-trifluorobenzoylmalonate were added 20 ml of water and 30 mg of p-toluenesulfonic acid, followed by heating and refluxing for 2.5 hours. After cooling, the mixture was extracted with diethyl ether. The extract was dried over magnesium sulfate and concentrated to give 3.3 g of ethyl 2-methyl-3,4,6-trifluorobenzoylacetate.

후처리

  1. temperatureby heating
  2. temperaturerefluxing for 2.5 hours
  3. temperatureAfter cooling
  4. extractionthe mixture was extracted with diethyl ether
  5. dry with materialThe extract was dried over magnesium sulfate
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-991ad80c1386408da891fc79a06e5c96
출처 데이터셋
uspto-grants-2001_12
특허 번호
US06333431B1

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