p-Toluenesulfonic acid → Ethyl (3,4,6-Trifluoro-2-methylbenzoyl)acetate
반응식
[CH3:1][C:2]1[C:20]([F:21])=[C:19]([F:22])[CH:18]=[C:17]([F:23])[C:3]=1[C:4]([CH:6](C(OCC)=O)[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5].C1(C)C=CC(S(O)(=O)=O)=CC=1>O>[CH3:1][C:2]1[C:20]([F:21])=[C:19]([F:22])[CH:18]=[C:17]([F:23])[C:3]=1[C:4]([CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5]참가 물질
4
실험 절차
To 5.1 g of diethyl 2-methyl-3,4,6-trifluorobenzoylmalonate were added 20 ml of water and 30 mg of p-toluenesulfonic acid, followed by heating and refluxing for 2.5 hours. After cooling, the mixture was extracted with diethyl ether. The extract was dried over magnesium sulfate and concentrated to give 3.3 g of ethyl 2-methyl-3,4,6-trifluorobenzoylacetate.
후처리
- temperatureby heating
- temperaturerefluxing for 2.5 hours
- temperatureAfter cooling
- extractionthe mixture was extracted with diethyl ether
- dry with materialThe extract was dried over magnesium sulfate
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-991ad80c1386408da891fc79a06e5c96
- 출처 데이터셋
- uspto-grants-2001_12
- 특허 번호
- US06333431B1
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