Hydrochloric Acid → HCID 70676330, 화합물

HRID 2271497노트

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HRID 2271497 반응식
Cl.[Cl:2][C:3]1[CH:4]=[C:5]([CH:10]([O:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:11]2[CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12]2)[CH:6]=[CH:7][C:8]=1[Cl:9]>CO>[ClH:2].[Cl:2][C:3]1[CH:4]=[C:5]([CH:10]([O:22][C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:11]2[CH2:14][NH:13][CH2:12]2)[CH:6]=[CH:7][C:8]=1[Cl:9]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 70676150HCID 70676150, 화합물

생성물 1

HCID 70676330HCID 70676330, 화합물수율 97%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
60 °C

실험 절차

1N HCl (3 mL) was added to 10 mL of tertiary butyl 3-((3,4-dichlorophenyl)(phenoxy)methyl)azetidine-1-carboxylate (150 mg, 0.352 mmol) dissolved in a methanol solution, and heated to reflux at 60° C. for one day. Thereafter, the solvent of the reaction mixture was removed by reduced pressure evaporation to obtain the title compound.

후처리

  1. temperatureheated
  2. customThereafter, the solvent of the reaction mixture was removed by reduced pressure evaporation

출처 및 근거

ORD 기록
ord-93bc20a08d9041a0b7ad8d0f4530eab1
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09120771B2

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