Hydrochloric Acid → HCID 178479265, 화합물

HRID 2271570노트

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HRID 2271570 반응식
[N:1]1([C@H:6]2[CH2:11][CH2:10][C@H:9]([NH:12]C(=O)OC(C)(C)C)[CH2:8][CH2:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:20].O>C1COCC1>[ClH:20].[N:1]1([C@H:6]2[CH2:11][CH2:10][C@H:9]([NH2:12])[CH2:8][CH2:7]2)[CH2:2][CH2:3][CH2:4][CH2:5]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 178453978HCID 178453978, 화합물

생성물 1

HCID 178479265HCID 178479265, 화합물수율 99%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
65 °C

실험 절차

To a solution of tert-butyl trans-4-(pyrrolidin-1-yl)cyclohexylcarbamate (399 mg, 1.44 mmol) in THF (12 mL) was added aqueous 6 N HCl (6 mL) and water (6 mL) and the reaction mixture was heated at 65° C. for 18 ht. The reaction mixture was cooled and concentrated to afford the desired product (350 mg, >99%) as an off-white solid: ESI MS m/z 169 [C10H20N2+H]+.

후처리

  1. temperatureThe reaction mixture was cooled
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-8b128e8878524106bc9ff4bbe7d9d355
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09120749B2

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