Hydrochloric Acid → 3-(Phenylsulfonyl)-4-piperazin-1-yl-1H-indazole Hydrochloride

HRID 227307

반응식

HRID 227307 반응식
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:22]=[CH:21][CH:20]=[C:19]3[C:15]=2[C:16]([S:23]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)(=[O:25])=[O:24])=[N:17][NH:18]3)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:32]>CO.CCOCC>[ClH:32].[C:26]1([S:23]([C:16]2[C:15]3[C:19](=[CH:20][CH:21]=[CH:22][C:14]=3[N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)[NH:18][N:17]=2)(=[O:25])=[O:24])[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 178452229HCID 178452229, 화합물

생성물 1

HCID 1784797763-(Phenylsulfonyl)-4-piperazin-1-yl-1H-indazole Hydrochloride수율 40%

시약·촉매·용매 2

HCID 887Methanol용매HCID 3283Diethyl Ether용매

실험 절차

A solution of 4-[4-(t-butoxycarbonyl)piperazin-1-yl]-3-(phenylsulfonyl)-1H-indazole (0.022 g, 0.050 mmol) in methanol is treated with a 2 M solution of HCl in ether (0.4 mL), heated at reflux temperature for 1 h, cooled to room temperature and evaporated to dryness. The residue is re-dissolved in methanol and concentrated. Repeating this procedure three more times affords the title product as a white solid, 0.009 g (40% yield), identified by NMR and mass spectral analyses.

후처리

  1. temperatureheated
  2. temperatureat reflux temperature for 1 h
  3. customevaporated to dryness
  4. dissolutionThe residue is re-dissolved in methanol
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-0b5efa1436b5499cbc871f1eee9c7833
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07560470B2

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