Lithium hydroxide, monohydrate → lithium (R)-4-(1-(1-(3-fluorobenzyl)piperidine-2-carboxamido)cyclopropyl)benzoate
반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:28]=[CH:29][CH:30]=1)[CH2:5][N:6]1[CH2:11][CH2:10][CH2:9][CH2:8][C@@H:7]1[C:12]([NH:14][C:15]1([C:18]2[CH:27]=[CH:26][C:21]([C:22]([O:24]C)=[O:23])=[CH:20][CH:19]=2)[CH2:17][CH2:16]1)=[O:13].O[Li:32].O>>[F:1][C:2]1[CH:3]=[C:4]([CH:28]=[CH:29][CH:30]=1)[CH2:5][N:6]1[CH2:11][CH2:10][CH2:9][CH2:8][C@@H:7]1[C:12]([NH:14][C:15]1([C:18]2[CH:19]=[CH:20][C:21]([C:22]([O-:24])=[O:23])=[CH:26][CH:27]=2)[CH2:16][CH2:17]1)=[O:13].[Li+:32]참가 물질
3
실험 절차
The title compound (E11) (61 mg) was prepared according to the general procedure for esters hydrolysis starting from (R)-methyl 4-(1-(1-(3-fluorobenzyl)piperidine-2-carboxamido)cyclopropyl)benzoate (D28) (62 mg). (LiOH H2O: 3 eq; reaction time: 3 hrs)
출처 및 근거
- ORD 기록
- ord-d3ce8f300159458e9e0e8f1c6863abb2
- 출처 데이터셋
- uspto-grants-2015_09
- 특허 번호
- US09120824B2
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