Sodium Carbonate → 7,8-Dibromo-2-methoxy-[1,5]naphthyridine

HRID 2273210노트

반응식

HRID 2273210 반응식
P(Br)(Br)[Br:2].[Br:5][C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1O)=[N:13][C:12]([O:17][CH3:18])=[CH:11][CH:10]=2.C(=O)([O-])[O-].[Na+].[Na+]>CN(C)C=O>[Br:5][C:6]1[C:15]([Br:2])=[C:14]2[C:9]([CH:10]=[CH:11][C:12]([O:17][CH3:18])=[N:13]2)=[N:8][CH:7]=1

참가 물질

5

반응물 3

HCID 10340Sodium CarbonateHCID 24614Phosphorus tribromideHCID 178487833HCID 178487833, 화합물

생성물 1

HCID 672578837,8-Dibromo-2-methoxy-[1,5]naphthyridine수율 80.6%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Phosphorus tribromide (140 mg, 0.53 mmol, 1.3 eq) is added at 0° C. to a stirred suspension of 3-bromo-6-methoxy-[1,5]naphthyridin-4-ol (100 mg, 0.39 mmol, 1.0 eq) in N,N-dimethylformamide (1 mL). After 2 hours stirring at room temperature, the reaction mixture is poured into saturated sodium carbonate aqueous solution (50 mL). The resulting suspension is filtered and the cake is washed with water and methanol to afford 7,8-dibromo-2-methoxy-[1,5]naphthyridine as a white solid (100 mg, 80% yield).

후처리

  1. filtrationThe resulting suspension is filtered
  2. washthe cake is washed with water and methanol

출처 및 근거

ORD 기록
ord-92f30c14292e46ff82bddab91d9a0b1e
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09120822B2

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