Acetic Anhydride → 1,1-Cyclohexanediacetic Anhydride

HRID 227340

반응식

HRID 227340 반응식
[C:1]1([CH2:11][C:12]([OH:14])=[O:13])([CH2:7][C:8]([OH:10])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(OC(=O)C)(=O)C>>[C:1]12([CH2:7][C:8](=[O:10])[O:14][C:12](=[O:13])[CH2:11]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]2

참가 물질

3

반응물 2

HCID 7918Acetic AnhydrideHCID 78061Cyclohexanediacetic acid

생성물 1

HCID 27342891,1-Cyclohexanediacetic Anhydride수율 100%

실험 절차

A suspension of 1,1-cyclohexanediacetic acid (39.95 mmol) in acetic anhydride (159.8 mmol) was refluxed gently until a clear solution was obtained (ca. 1 h). The reaction mixture was kept at reflux for another hour until the reaction was complete. The reaction mixture was cooled to room temperature and acetic acid and excess acetic anhydride were removed under vacuum to afford 7.28 g (100%) of (3). 1H NMR (CDCl3): 2.65 (4H, s); 1.54-1.43 (10H, m).

후처리

  1. temperaturewas refluxed gently until a clear solution
  2. customwas obtained (ca. 1 h)
  3. temperatureat reflux for another hour until the reaction
  4. customacetic acid and excess acetic anhydride were removed under vacuum

출처 및 근거

ORD 기록
ord-2b67861576314e4ebf8b42096805df53
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07560483B2

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