Hydrochloric Acid → 3-Cyclopropyl-1,2-oxazole-4-carboxylic acid

HRID 2273573노트

반응식

HRID 2273573 반응식
C([O:3][C:4]([C:6]1[C:7]([CH:11]2[CH2:13][CH2:12]2)=[N:8][O:9][CH:10]=1)=[O:5])C.[OH-].[K+].Cl>C(O)C.O.O>[CH:11]1([C:7]2[C:6]([C:4]([OH:5])=[O:3])=[CH:10][O:9][N:8]=2)[CH2:12][CH2:13]1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 57424032HCID 57424032, 화합물

생성물 1

HCID 450847723-Cyclopropyl-1,2-oxazole-4-carboxylic acid

시약·촉매·용매 2

HCID 962Water용매HCID 19096565Water ethanol용매

실험 절차

5.6 g (31 mmol) of 3-Cyclopropyl-isoxazole-4-carboxylic acid ethyl ester were slowly added to a solution of 6.1 g (93 mmol, 85% purity) of potassium hydroxide in ethanol/water (1:3, 100 ml) at 0° C. The reaction mixture was stirred at room temperature for 16 h, diluted with water, acidified (pH=2) with 20% aqueous HCl and extracted with dichloromethane. The combined organic layers were dried over sodium sulfate, filtered and the solvent was removed to yield 4.7 g (94%, 95% purity) of the title compound which did not need further purification.

후처리

  1. extractionextracted with dichloromethane
  2. dry with materialThe combined organic layers were dried over sodium sulfate
  3. filtrationfiltered
  4. customthe solvent was removed

출처 및 근거

ORD 기록
ord-53b075df594b4885bcb304873d7abb92
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09125414B2

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