Ammonium formate → 1-N-(2-methoxyethyl)benzene-1,2-diamine
반응식
C([O-])=O.[NH4+].[CH3:5][O:6][CH2:7][CH2:8][NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[N+:16]([O-])=O>[Pd].CO>[CH3:5][O:6][CH2:7][CH2:8][NH:9][C:10]1[C:11]([NH2:16])=[CH:12][CH:13]=[CH:14][CH:15]=1참가 물질
5
실험 절차
Ammonium formate (727 mg, 11.3 mmol) followed by a catalytic amount of palladium on carbon (5%) is added to a solution of N-(2-methoxyethyl)-2-nitroaniline (426 mg, 2.17 mmol) in methanol. The mixture may be refluxed for an appropriate time period (such as overnight), cooled to an appropriate temperature (such as room temperature) and filtered. The filtrate may be concentrated and the residue may purified by Biotage column chromatography to give N1-(2-methoxyethyl)benzene-1,2-diamine (319 mg)
후처리
- temperatureThe mixture may be refluxed for an appropriate time period (such as overnight)
- filtrationfiltered
- concentrationThe filtrate may be concentrated
- customthe residue may purified by Biotage column chromatography
출처 및 근거
- ORD 기록
- ord-937e34ca3b234f7fba1c9fe743faf356
- 출처 데이터셋
- uspto-grants-2015_09
- 특허 번호
- US09125901B2
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