N-bromobutanimide → 2-Amino-5-bromo-3-fluorobenzoic acid

HRID 2274220

반응식

HRID 2274220 반응식
[NH2:1][C:2]1[C:10]([F:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Br:12]N1C(=O)CCC1=O>ClCCl>[NH2:1][C:2]1[C:10]([F:11])=[CH:9][C:8]([Br:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 5864082-Amino-3-fluorobenzoic acid

생성물 1

HCID 404245972-Amino-5-bromo-3-fluorobenzoic acid수율 78%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 2-amino-3-fluorobenzoic acid (10.85 g, 70 mmol) in dichloromethane (175 mL) was added N-bromosuccinimide (12.46 g, 70 mmol), and the mixture was stirred at RT for 2 h. LCMS showed the reaction was completed. The precipitate was filtered and washed with dichloromethane (100 mL*3) to give the title compound (12.7 g, 78%) as a grey solid, which was directly used in the next step without further purification. MS (ES+) C7H5BrFNO2 requires: 233, 235. Found: 232, 234 [M−H]−.

후처리

  1. filtrationThe precipitate was filtered
  2. washwashed with dichloromethane (100 mL*3)

출처 및 근거

ORD 기록
ord-6727622cad8a413ba3561916ceaa6d00
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09126951B2

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