Hydrochloric Acid → (R)-(3-Aminopiperidin-1-yl)(7-methoxy-1-methyl-2-(1-(2,2,2-trifluoroethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-benzo[d]imidazol-5-yl)methanone, hydrochloride

HRID 2275049노트

반응식

HRID 2275049 반응식
[NH2:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][N:4]([C:8]([C:10]2[CH:33]=[C:32]([O:34][CH3:35])[C:13]3[N:14]([CH3:31])[C:15]([C:17]4[N:25]([CH2:26][C:27]([F:30])([F:29])[F:28])[C:20]5=[N:21][CH:22]=[CH:23][CH:24]=[C:19]5[CH:18]=4)=[N:16][C:12]=3[CH:11]=2)=[O:9])[CH2:3]1.[ClH:36]>C(Cl)Cl>[ClH:36].[NH2:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][N:4]([C:8]([C:10]2[CH:33]=[C:32]([O:34][CH3:35])[C:13]3[N:14]([CH3:31])[C:15]([C:17]4[N:25]([CH2:26][C:27]([F:30])([F:29])[F:28])[C:20]5=[N:21][CH:22]=[CH:23][CH:24]=[C:19]5[CH:18]=4)=[N:16][C:12]=3[CH:11]=2)=[O:9])[CH2:3]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 73052940(R)-(3-Aminopiperidin-1-yl)(7-methoxy-1-methyl-2-(1-(2,2,2-trifluoroethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-benzo[d]imidazol-5-yl)methanone

생성물 1

HCID 131733421(R)-(3-Aminopiperidin-1-yl)(7-methoxy-1-methyl-2-(1-(2,2,2-trifluoroethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-benzo[d]imidazol-5-yl)methanone, hydrochloride수율 102.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

(R)-(3-Aminopiperidin-1-yl)(7-methoxy-1-methyl-2-(1-(2,2,2-trifluoroethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-benzo[d]imidazol-5-yl)methanone (1.5073 g) was dissolved in DCM (5 ml) and HCl (2M in diethyl ether) (1.5 ml, 3.00 mmol) was added to the solution. The solvent was then removed under nitrogen and concentrated under vacuum to afford the title compound as a white solid (1.61 g)

후처리

  1. customThe solvent was then removed under nitrogen
  2. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-b7ce77abccff4a6b8331b11354f0e5dc
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09127003B2

반응 노트

불러오는 중…