Hydrochloric Acid → HCID 178445075, 화합물

반응식

[C:1]1([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[CH:6]=[CH:5][C:4]([CH2:7][C@@H:8]([NH:23][C:24]([C:26]2[N:27]=[N:28][NH:29][CH:30]=2)=[O:25])[CH2:9][C@@:10]([CH3:22])([CH2:14][O:15]C2CCCCO2)[C:11](O)=[O:12])=[CH:3][CH:2]=1.[CH2:37]([OH:43])[CH2:38][CH2:39][CH2:40][CH2:41][CH3:42].Cl.O1CCOCC1>>[CH2:37]([O:43][C:11](=[O:12])[C@@:10]([CH2:14][OH:15])([CH3:22])[CH2:9][C@H:8]([NH:23][C:24]([C:26]1[N:27]=[N:28][NH:29][CH:30]=1)=[O:25])[CH2:7][C:4]1[CH:3]=[CH:2][C:1]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)=[CH:6][CH:5]=1)[CH2:38][CH2:39][CH2:40][CH2:41][CH3:42]

참가 물질

반응물 4

HCID 313Hydrochloric Acid

HCID 81031-Hexanol

HCID 312751,4-Dioxane

HCID 178458454HCID 178458454, 화합물

생성물 1

HCID 178445075HCID 178445075, 화합물수율 51.8%

반응 조건

온도: 60 °C

실험 절차

(2S,4R)-5-Biphenyl-4-yl-2-methyl-2-(tetrahydropyran-2-yloxymethyl)-4-[(1H-1,2,3-triazole-4-carbonyl)amino]pentanoic acid (100 mg, 0.2 mmol) was combined with 1-hexanol (0.3 mL, 2 mmol) and 4 M HCl in 1,4-dioxane (0.3 mL, 1 mmol). The mixture was stirred for 2 hours at 60° C. The mixture was concentrated under reduced pressure and the residue was purified by reverse phase chromatography to yield the title compound (51 mg). MS m/z [M+H]+ calc'd for C28H36N4O4, 493.27. found 493.