Diisopropylethylamine → HCID 89964653, 화합물

HRID 2275502노트

반응식

HRID 2275502 반응식
[CH2:1]([C:5]1[CH:9]=[C:8]([C:10]([OH:12])=O)[O:7][N:6]=1)[CH:2]([CH3:4])[CH3:3].CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.[NH2:37][C@H:38]([CH2:47][C:48]1[CH:53]=[CH:52][C:51]([C:54]2[CH:59]=[C:58]([Cl:60])[CH:57]=[CH:56][C:55]=2[F:61])=[CH:50][CH:49]=1)[CH2:39][C@:40]([CH2:45][OH:46])([CH3:44])[C:41]([OH:43])=[O:42].CCN(C(C)C)C(C)C>CN(C=O)C>[Cl:60][C:58]1[CH:57]=[CH:56][C:55]([F:61])=[C:54]([C:51]2[CH:50]=[CH:49][C:48]([CH2:47][C@@H:38]([NH:37][C:10]([C:8]3[O:7][N:6]=[C:5]([CH2:1][CH:2]([CH3:3])[CH3:4])[CH:9]=3)=[O:12])[CH2:39][C@:40]([CH2:45][OH:46])([CH3:44])[C:41]([OH:43])=[O:42])=[CH:53][CH:52]=2)[CH:59]=1

참가 물질

6

반응물 4

HCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 252207923-Isobutylisoxazole-5-carboxylic acidHCID 89964351HCID 89964351, 화합물

생성물 1

HCID 89964653HCID 89964653, 화합물수율 1.1%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매2회

실험 절차

3-Isobutylisoxazole-5-carboxylic acid (9 mg, 55 μmol) and HATU (20.8 mg, 55 μmol) were combined in DMF (0.2 mL) and allowed to stand at room temperature for 10 minutes. (2S,4R)-4-Amino-5-(5′-chloro-2′-fluorobiphenyl-4-yl)-2-hydroxymethyl-2-methylpentanoic acid (20 mg, 55 μmol) in DMF and DIPEA (28.6 μL, 164 μmol) were added, and the resulting mixture was stirred for 20 minutes at room temperature. The mixture was concentrated under reduced pressure and the residue was dissolved in AcOH purified by preparative HPLC to yield the title compound (0.3 mg). MS m/z [M+H]+ calc'd for C27H30ClFN2O5, 517.18. found 517.2.

후처리

  1. concentrationThe mixture was concentrated under reduced pressure
  2. dissolutionthe residue was dissolved in AcOH
  3. custompurified by preparative HPLC

출처 및 근거

ORD 기록
ord-54fb97cb167c48659e4060e328f6bd42
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09126956B2

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