Acetyl chloride → 5-Chloroisatoic anhydride
반응식
[NH2:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7](Cl)[C:3]=1[C:4]([OH:6])=[O:5].Cl[C:13](OCC)=[O:14].C([Cl:21])(=O)C>O1CCOCC1>[Cl:21][C:8]1[CH:7]=[C:3]2[C:4]([O:6][C:13](=[O:14])[NH:1][C:2]2=[CH:10][CH:9]=1)=[O:5]참가 물질
5
반응 조건
- 온도
- 50 °C
실험 절차
2-Amino-6-chlorobenzoic acid (30 g) was suspended in 1,4-dioxane (225 ml) and ethyl chloroformate (75 ml) was added. The mixture was heated at reflux for 1 hour, then cooled to 50° C., and acetyl chloride (75 ml) was added. The mixture was stirred for 10 hours, after which the precipitated product was filtered off and washed with toluene. Drying in vacuum yields 5-chloroisatoic anhydride (33 g, 97% yield).
후처리
- temperatureThe mixture was heated
- temperatureat reflux for 1 hour
- filtrationafter which the precipitated product was filtered off
- washwashed with toluene
- customDrying in vacuum
출처 및 근거
- ORD 기록
- ord-95d444a5725d4f3d89bff7eb6a69388c
- 출처 데이터셋
- uspto-grants-2009_07
- 특허 번호
- US07560557B2
반응 노트
불러오는 중…