Water → HCID 3816170, 화합물

HRID 2275784노트

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HRID 2275784 반응식
[NH2:1][CH:2]([C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1)[CH2:3][C:4]([OH:6])=[O:5].[C:14]1(=O)[O:19][C:17](=[O:18])[C:16]2=[CH:20][CH:21]=[CH:22][CH:23]=[C:15]12.O>CN(C=O)C>[O:18]=[C:17]1[C:16]2[C:15](=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:14](=[O:19])[N:1]1[CH:2]([C:7]1[CH:8]=[CH:9][C:10]([F:13])=[CH:11][CH:12]=1)[CH2:3][C:4]([OH:6])=[O:5]

참가 물질

5

반응물 3

HCID 962WaterHCID 6811Phthalic AnhydrideHCID 5798853-Amino-3-(4-fluorophenyl)propanoic acid

생성물 1

HCID 3816170HCID 3816170, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
135 °C

실험 절차

2.0 g of rac-3-amino-3-(4-fluorophenyl)propanoic acid (10.92 mmol) and 1.62 g of phthalic anhydride (10.92 mmol) were dissolved in 9 ml of DMF and heated at reflux at 135° C. overnight. The reaction solution was added to about 200 ml of water. The solid formed was stirred at RT for about 30 min and then filtered off, washed with water and dried under high vacuum. This gave 3.43 g of the title compound (86% of theory, purity about 86%).

후처리

  1. temperatureheated
  2. customThe solid formed
  3. filtrationfiltered off
  4. washwashed with water
  5. customdried under high vacuum

출처 및 근거

ORD 기록
ord-be1cb000e0fa40c8a04784395db9e57c
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09126998B2

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