Hydrochloric Acid → HCID 88415079, 화합물

HRID 2275853노트

반응식

HRID 2275853 반응식
[ClH:1].[NH2:2][C:3]([CH3:17])([C:13]([F:16])([F:15])[F:14])[CH2:4][NH:5]C(=O)OC(C)(C)C>O1CCOCC1>[ClH:1].[ClH:1].[F:14][C:13]([F:16])([F:15])[C:3]([CH3:17])([NH2:2])[CH2:4][NH2:5]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 90136051rac-tert-Butyl (2-amino-3,3,3-trifluoro-2-methylpropyl)carbamate

생성물 1

HCID 88415079HCID 88415079, 화합물

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

188 ml of 4 M hydrogen chloride in dioxane were added to 15 g (61.9 mmol) of rac-tert-butyl (2-amino-3,3,3-trifluoro-2-methylpropyl)carbamate from Example 245A in dioxane (188 ml). The reaction mixture was stirred at RT for 16 h and then concentrated and kept under argon. This gave 14.4 g (108% of theory) of the target compound which was not purified any further.

후처리

  1. concentrationconcentrated
  2. customThis gave 14.4 g (108% of theory) of the target compound which was not purified any further

출처 및 근거

ORD 기록
ord-b67c0ac48e074a4e9172ca4c5ef8b0c1
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09126998B2

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