1-Methylpiperazine → 6-[(4-Methylpiperazin-1-yl)methyl]-5-(4-nitrophenyl)thieno[2,3-d]pyrimidin-4-amine

HRID 227607노트

반응식

HRID 227607 반응식
Br[CH2:2][C:3]1[S:12][C:6]2[N:7]=[CH:8][N:9]=[C:10]([NH2:11])[C:5]=2[C:4]=1[C:13]1[CH:18]=[CH:17][C:16]([N+:19]([O-:21])=[O:20])=[CH:15][CH:14]=1.[CH3:22][N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>CN(C=O)C>[CH3:22][N:23]1[CH2:28][CH2:27][N:26]([CH2:2][C:3]2[S:12][C:6]3[N:7]=[CH:8][N:9]=[C:10]([NH2:11])[C:5]=3[C:4]=2[C:13]2[CH:18]=[CH:17][C:16]([N+:19]([O-:21])=[O:20])=[CH:15][CH:14]=2)[CH2:25][CH2:24]1

참가 물질

4

반응물 2

HCID 531671-MethylpiperazineHCID 590995626-(Bromomethyl)-5-(4-nitrophenyl)thieno[2,3-d]pyrimidin-4-amine

생성물 1

HCID 116251676-[(4-Methylpiperazin-1-yl)methyl]-5-(4-nitrophenyl)thieno[2,3-d]pyrimidin-4-amine수율 33.1%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of Example 57A (330 mg) and N-methylpiperazine (0.3 mL, 2.71 mmol) in DMF (6 mL) was stirred at room temperature overnight and concentrated. The concentrate was absorbed on silica gel and purified by flash column chromatography with ethyl acetate followed by 12% methanol/dichloromethane to provide 115 mg the desired product. Rf=0.38 (12% methanol/dichloromethane).

후처리

  1. concentrationconcentrated
  2. customThe concentrate was absorbed on silica gel
  3. custompurified by flash column chromatography with ethyl acetate

출처 및 근거

ORD 기록
ord-5abe58e1334e4a13a08db1de6bc4fb3b
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07560552B2

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