3-Amino-3-(4-nitrophenyl)-2-cyanoacrylonitrile → HCID 59099563, 화합물

HRID 227616

반응식

HRID 227616 반응식
[NH2:1][C:2]([C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][CH:9]=1)=[C:3]([C:6]#[N:7])[C:4]#[N:5].P([O-])(OCC)(SCC)=[S:18]>C(O)C.O>[NH2:1]/[C:2](/[C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][CH:9]=1)=[C:3](/[C:4]#[N:5])\[C:6](=[S:18])[NH2:7]

참가 물질

5

반응물 2

HCID 140279223-Amino-3-(4-nitrophenyl)-2-cyanoacrylonitrileHCID 53249491Diethyldithiophosphate

생성물 1

HCID 59099563HCID 59099563, 화합물수율 95%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

A suspension of Example 96C (2.1 g, 9.8 mmol) and 90% diethyl dithiophosphate (1.8 mL, 10.8 mmol) in ethanol (15 mL) and water (15 mL) was heated to reflux for 24 hours, cooled to room temperature, poured into ice water (300 mL), and filtered. The filter cake was dried to provide 2.3 g (95% yield) of the desired product. MS(ESI(−)) m/e 247 (M−H)−.

후처리

  1. temperatureto reflux for 24 hours
  2. filtrationfiltered
  3. customThe filter cake was dried

출처 및 근거

ORD 기록
ord-631e3ab4d3404d2c9f8160fcdda6472d
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07560552B2

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