Formamide → 3-(4-Nitrophenyl)isothiazolo[5,4-d]pyrimidin-4-amine

HRID 227618노트

반응식

HRID 227618 반응식
[NH2:1][C:2]1[S:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=O)=[CH:9][CH:8]=2)[C:3]=1[C:16]#[N:17].[OH2:18].[CH:19]([NH2:21])=O>>[N+:13]([C:10]1[CH:9]=[CH:8][C:7]([C:4]2[C:3]3[C:2](=[N:1][CH:19]=[N:21][C:16]=3[NH2:17])[S:6][N:5]=2)=[CH:12][CH:11]=1)([O-:15])=[O:18]

참가 물질

4

반응물 3

HCID 713FormamideHCID 962WaterHCID 690551855-Amino-3-(4-nitrophenyl)isothiazole-4-carbonitrile

생성물 1

HCID 444147423-(4-Nitrophenyl)isothiazolo[5,4-d]pyrimidin-4-amine수율 84%

실험 절차

A mixture of Example 96E (200 mg) in formamide (5 mL) in a capped vial was heated to 210° C. in a Smith microwave oven at 300W for 25 minutes, poured into water, and filtered. The filter cake was dried to provide 2.02 g (84% yield) of the desired product. MS(ESI(+)) m/e 274 (M+H)+.

후처리

  1. filtrationfiltered
  2. customThe filter cake was dried

출처 및 근거

ORD 기록
ord-cb325f8a8a724487b8bc4591735c1aec
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07560552B2

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