Methyl acetoacetate → Methyl 3-(2-fluorophenyl)-5-methylisoxazole-4-carboxylate

HRID 2276403

반응식

HRID 2276403 반응식
[F:1][C:2]1[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=1[C:4](Cl)=[N:5][OH:6].[CH3:12][O:13][C:14](=[O:19])[CH2:15][C:16]([CH3:18])=O.C[O-].[Na+]>CO>[CH3:12][O:13][C:14]([C:15]1[C:4]([C:3]2[CH:8]=[CH:9][CH:10]=[CH:11][C:2]=2[F:1])=[N:5][O:6][C:16]=1[CH3:18])=[O:19]

참가 물질

5

반응물 3

HCID 7757Methyl acetoacetateHCID 37581182-fluoro-N-hydroxybenzenecarboximidoyl chlorideHCID 10942334Sodium Methoxide

생성물 1

HCID 18756272Methyl 3-(2-fluorophenyl)-5-methylisoxazole-4-carboxylate수율 72.3%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

In a similar manner as described in Preparation Example 17, by using methanol (160 mL), 2-fluoro-N-hydroxybenzimidoyl chloride (8.00 g, 46.09 mmol), methylacetoacetate (10.07 g, 92.18 mmol) and sodium methoxide (7.47 g, 138.27 mmol), a white solid required compound (7.84 g, 33.33 mmol, 72%) was obtained.

후처리

  1. customIn a similar manner as described in Preparation Example 17

출처 및 근거

ORD 기록
ord-c8ed9da7a8954d24bc2f2261ffa694b1
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09132126B2

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