1-(2-Fluorophenyl)piperazine → (3-(2-Fluorophenyl)-5-methylisoxazol-4-yl)(4-(2-fluorophenyl)piperazine-1-yl)methanone

HRID 2276446

반응식

HRID 2276446 반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:12]([C:13]([OH:15])=O)=[C:11]([CH3:16])[O:10][N:9]=1.Cl.C(N=C=NCCCN(C)C)C.[F:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=1[N:36]1[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]1>ClCCl>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:12]([C:13]([N:39]2[CH2:38][CH2:37][N:36]([C:31]3[CH:32]=[CH:33][CH:34]=[CH:35][C:30]=3[F:29])[CH2:41][CH2:40]2)=[O:15])=[C:11]([CH3:16])[O:10][N:9]=1

참가 물질

5

반응물 3

HCID 705291-(2-Fluorophenyl)piperazineHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 64841013-(2-Fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid

생성물 1

HCID 66576866(3-(2-Fluorophenyl)-5-methylisoxazol-4-yl)(4-(2-fluorophenyl)piperazine-1-yl)methanone수율 82.1%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

In a similar manner as described in Example 1, by using dichloromethane (30 mL), 3-(2-fluorophenyl)-5-methylisoxazol-4-carboxylic acid (407 mg, 1.84 mmol), 1-ethyl-3-(dimethylaminopropyl)carbodiimide hydrochloride (388 mg, 2.02 mmol) and 1-(2-fluorophenyl)piperazine (332 mg, 1.84 mmol), a white solid required compound (578 mg, 1.51 mmol, 82%) was obtained.

출처 및 근거

ORD 기록
ord-a3801502b09249f183e422b0e6da7e67
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09132126B2

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