1-(3,4-Dichlorophenyl)piperazine → (4-(3,4-Dichlorophenyl)piperazine-1-yl)(3-(2-fluorophenyl)-5-methylisoxazol-4-yl)methanone

HRID 2276447노트

반응식

HRID 2276447 반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:12]([C:13]([OH:15])=O)=[C:11]([CH3:16])[O:10][N:9]=1.Cl.C(N=C=NCCCN(C)C)C.[Cl:29][C:30]1[CH:31]=[C:32]([N:37]2[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]2)[CH:33]=[CH:34][C:35]=1[Cl:36]>ClCCl>[Cl:29][C:30]1[CH:31]=[C:32]([N:37]2[CH2:42][CH2:41][N:40]([C:13]([C:12]3[C:8]([C:3]4[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=4[F:1])=[N:9][O:10][C:11]=3[CH3:16])=[O:15])[CH2:39][CH2:38]2)[CH:33]=[CH:34][C:35]=1[Cl:36]

참가 물질

5

반응물 3

HCID 936011-(3,4-Dichlorophenyl)piperazineHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 64841013-(2-Fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid

생성물 1

HCID 66576940(4-(3,4-Dichlorophenyl)piperazine-1-yl)(3-(2-fluorophenyl)-5-methylisoxazol-4-yl)methanone수율 74%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

In a similar manner as described in Example 1, by using dichloromethane (30 mL), 3-(2-fluorophenyl)-5-methylisoxazol-4-carboxylic acid (407 mg, 1.84 mmol), 1-ethyl-3-(dimethylaminopropyl)carbodiimide hydrochloride (388 mg, 2.02 mmol) and 1-(3,4-dichlorophenyl)piperazine (425 mg, 1.84 mmol), a white solid required compound (587 mg, 1.35 mmol, 74%) was obtained.

출처 및 근거

ORD 기록
ord-38ca2cce7b8b421b9a5437e35f8ad2a2
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09132126B2

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