Water → HCID 66798076, 화합물

HRID 227645노트

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HRID 227645 반응식
[Cl:1][C:2]1[C:3]([CH2:12][C:13]#[N:14])=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[CH:15](C)(C)[C:16]([O-])=O.[K+].C(I)C.O>C1COCC1.C(OCC)(=O)C>[Cl:1][C:2]1[C:3]([CH:12]([CH2:15][CH3:16])[C:13]#[N:14])=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:9])[F:10])[CH:7]=1

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7

반응물 4

HCID 962WaterHCID 6340IodoethaneHCID 162272722-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]acetonitrileHCID 23677462Potassium isobutyrate

생성물 1

HCID 66798076HCID 66798076, 화합물

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매2회HCID 8857Ethyl Acetate용매

실험 절차

199 g (0.9 mol) of 3 of [3-chloro-5-(trifluoromethyl)-2-pyridinyl]acetonitrile are dissolved in 3 L of THF at −5° C. A solution of 106 g (0.945 mol) of potassium terbutanoate in 0.6 L of THF is slowly added to the reaction medium. After 2H, 147 g (0.945 mol) of ethyl iodide is added dropwise to the reaction mixture which is stirred overnight at room temperature. 3 L of water and 2 L of ethyl acetate are added to the reaction mixture, after separation, the aqueous phase is extracted twice with 500 mL of ethyl acetate.

후처리

  1. customafter separation
  2. extractionthe aqueous phase is extracted twice with 500 mL of ethyl acetate

출처 및 근거

ORD 기록
ord-60328439fbbd4d09aecf8eee3a86d213
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07560567B2

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