Diethyl bromomalonate → Ethyl 2-amino-4-hydroxythiazole-5-carboxylate

HRID 227655노트

반응식

HRID 227655 반응식
[NH2:1][C:2]([NH2:4])=[S:3].Br[CH:6]([C:12](OCC)=[O:13])[C:7]([O:9][CH2:10][CH3:11])=[O:8]>>[NH2:1][C:2]1[S:3][C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[C:12]([OH:13])[N:4]=1

참가 물질

3

반응물 2

HCID 69637Diethyl bromomalonateHCID 2723790Thiourea

생성물 1

HCID 224465Ethyl 2-amino-4-hydroxythiazole-5-carboxylate

실험 절차

Prepared according to literature procedure (Baldwin, J. J., et al. J. Med. Chem. 1980, 23, 65-70.) from thiourea and diethyl bromomalonate. MS m/z 189 (m+1).

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-3162e93119ca424ca91ab75237bc2af3
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07560568B2

반응 노트

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