Diisopropylethylamine → Tert-butyl (2-(7-oxo-7-((pyridin-3-ylmethyl)amino)heptanamido)phenyl)carbamate

To a solution of 7-((2-((tert-butoxycarbonyl)amino)phenyl)amino)-7-oxoheptanoic acid (1.2 g, 3.42 mmol) in DMF (10 mL) were added HBTU (1.43 g, 3.76 mmol), DIEA (1.3 g, 10.3 mmol) at room temperature. The resulting mixture was stirred for 10 min, then tpyridin-3-ylmethanamine (1.43 g, 3.76 mmol) was added to the reaction solution. The reaction mixture was stirred for 12 h at room temperature. The reaction was quenched with water (100 mL). The resulting mixture was extracted by EtOAc (100 mL×2). The organic layers were combined, dried with anhydrous Na2SO4 and concentrated under reduced pressure. The resulting solid was purified by column chromatography (elute: EtOAc:MeOH=100:1) to afford desired compound (1.2 g, yield 79.7%) as an off-white solid.

1. additiontpyridin-3-ylmethanamine (1.43 g, 3.76 mmol) was added to the reaction solution
2. stirringThe reaction mixture was stirred for 12 h at room temperature
3. customThe reaction was quenched with water (100 mL)
4. extractionThe resulting mixture was extracted by EtOAc (100 mL×2)
5. dry with materialdried with anhydrous Na2SO4
6. concentrationconcentrated under reduced pressure
7. customThe resulting solid was purified by column chromatography (elute: EtOAc:MeOH=100:1)

ORD 기록

ord-c1200769f06e4f3d99fe905f76b44db4

출처 데이터셋

uspto-grants-2015_09

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US09133105B2