Water → HCID 57755833, 화합물

HRID 227695

반응식

[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][N:8]=[C:7]2[NH2:13])([O-:3])=[O:2].[C:14](OC(=O)C)(=[O:16])[CH3:15].[OH2:21].N1[CH:27]=[CH:26]C=CC=1>>[C:14]([N:9]1[C:10]2[C:6](=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:12][CH:11]=2)[C:7]([NH:13][C:26](=[O:21])[CH3:27])=[N:8]1)(=[O:16])[CH3:15]

참가 물질

반응물 4

HCID 962Water

HCID 1049Pyridine

HCID 7918Acetic Anhydride

HCID 31366553-Amino-5-nitroindazole

생성물 1

HCID 57755833HCID 57755833, 화합물수율 91%

실험 절차

The product from Step (a) above (3.6 g, 20.2 mmol) was dissolved in pyridine (30 mL), acetic anhydride (4.15 mL, 44 mmol) was added and the mixture was stirred overnight at rt. The red solution was pouted into H2O and the resulting solid was filtered to give the title compunt as a red solid (4.8 g, 91%). NMR 1H NMR (400 MHz, DMSO-D6) δ 11.21 (br s, 1H), 9.08 (s, 1H), 8.46 (s, 2H), 2.51 (s, 3H), 2.23 (s, 3H) (MS m/z 263.2.0 [M+H]+

후처리

filtrationthe resulting solid was filtered

출처 및 근거

ORD 기록: ord-1a43f481a3d64d9fbdc7114267fb6e72
출처 데이터셋: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07560467B2

연결된 노트

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