Water → HCID 13540122, 화합물
반응식
C([O:3][C:4]([C:6]1[S:10][C:9]2[CH:11]=[C:12]([CH2:15][OH:16])[CH:13]=[CH:14][C:8]=2[CH:7]=1)=[O:5])C.O.[Li+].[OH-]>C1COCC1>[OH:16][CH2:15][C:12]1[CH:13]=[CH:14][C:8]2[CH:7]=[C:6]([C:4]([OH:5])=[O:3])[S:10][C:9]=2[CH:11]=1참가 물질
5
반응 조건
- 온도
- 50 °C
실험 절차
6-Hydroxymethyl-benzo[b]thiophene-2-carboxylic acid ethyl ester (2.4 g, 9.6 mmol, 1 eq) was dissolved in THF (10 mL, 4 vol) and water added (10 mL) along with LiOH (0.69 g, 28.8 mmol). The reaction mixture was stirred at 50° C. for 3 h and then concentrated to dryness and taken onto the next step without purification.
후처리
- concentrationconcentrated to dryness
- customtaken onto the next step without purification
출처 및 근거
- ORD 기록
- ord-6456dfba4d4d44798ea9159b2ddb5f67
- 출처 데이터셋
- uspto-grants-2015_09
- 특허 번호
- US09133104B2
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