Propionic Acid → 4-Hydroxy-6-methyl-3-propionyl-2H-pyran-2-one
반응식
[OH:1][C:2]1[CH:7]=[C:6]([CH3:8])[O:5][C:4](=[O:9])[CH:3]=1.C1CCC(N=C=NC2CCCCC2)CC1.[C:25](O)(=[O:28])[CH2:26][CH3:27]>C(Cl)Cl.CN(C1C=CN=CC=1)C>[OH:1][C:2]1[CH:7]=[C:6]([CH3:8])[O:5][C:4](=[O:9])[C:3]=1[C:25](=[O:28])[CH2:26][CH3:27]참가 물질
6
반응 조건
- 온도
- 0 °C
실험 절차
To 4-hydroxy-6-methyl-2H-pyran-2-one (18 g; 143 mmol; Aldrich) in 300 ml DCM at 0° C., was added TEA (20 ml; 143 mmol; Aldrich), DCC (30 g; 145 mmol; Aldrich), DMAP (5.25 g; 42.7 mmol; Aldrich) and propionic acid (11 ml; 147 mmol; Aldrich). The reaction mixture was stirred at 0° C. for 1 h, stirred at 25° C. for 18 h, and filtered via vacuum filtration. The filtrate was washed with 5% HCl, dried with brine and anhydrous Na2SO4, and evaporated to a white solid.
후처리
- stirringstirred at 25° C. for 18 h
- filtrationfiltered via vacuum filtration
- washThe filtrate was washed with 5% HCl
- dry with materialdried with brine and anhydrous Na2SO4
- customevaporated to a white solid
출처 및 근거
- ORD 기록
- ord-b104cc87cde049c7a8aa209a042c83f0
- 출처 데이터셋
- uspto-grants-2015_09
- 특허 번호
- US09133155B2
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