Bromomethylcyclopropane → Ethyl 5-(cyclopropylmethoxy)-3-fluoropyridine-2-carboxylate

반응식

[F:1][C:2]1[C:3]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[N:4][CH:5]=[C:6]([OH:8])[CH:7]=1.Br[CH2:15][CH:16]1[CH2:18][CH2:17]1>>[CH:16]1([CH2:15][O:8][C:6]2[CH:7]=[C:2]([F:1])[C:3]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[N:4][CH:5]=2)[CH2:18][CH2:17]1

참가 물질

반응물 2

HCID 81503Bromomethylcyclopropane

HCID 86731382Ethyl 3-fluoro-5-hydroxypicolinate

생성물 1

HCID 86731393Ethyl 5-(cyclopropylmethoxy)-3-fluoropyridine-2-carboxylate

실험 절차

Using ethyl 3-fluoro-5-hydroxypyridine-2-carboxylate and (bromomethyl)cyclopropane, and in the same manner as in Example 5, the title compound was obtained.

출처 및 근거

ORD 기록: ord-30eb75382c7c46caa0b1c5db1ba203a2
출처 데이터셋: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09133129B2

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