Bromomethylcyclopropane → N-((2S)-1-((2-(4-(cyclopropylmethoxy)-2-(2,2,2-trifluoroethoxy)phenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide

HRID 2277315노트

반응식

[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[O:16][C:17]3[CH:22]=[C:21]([O:23][CH2:24][C@@H:25]([NH:27][C:28](=[O:30])[CH3:29])[CH3:26])[N:20]=[CH:19][C:18]=3[N:31]=2)=[C:11]([O:32][CH2:33][C:34]([F:37])([F:36])[F:35])[CH:10]=1)[C:2]1[CH:7]=[CH:6]C=CC=1.BrCC1CC1>>[CH:2]1([CH2:1][O:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]3[O:16][C:17]4[CH:22]=[C:21]([O:23][CH2:24][C@@H:25]([NH:27][C:28](=[O:30])[CH3:29])[CH3:26])[N:20]=[CH:19][C:18]=4[N:31]=3)=[C:11]([O:32][CH2:33][C:34]([F:36])([F:37])[F:35])[CH:10]=2)[CH2:6][CH2:7]1

참가 물질

반응물 2

HCID 81503Bromomethylcyclopropane

HCID 86731399N-((2S)-1-((2-(4-(benzyloxy)-2-(2,2,2-trifluoroethoxy)phenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide

생성물 1

HCID 86731400N-((2S)-1-((2-(4-(cyclopropylmethoxy)-2-(2,2,2-trifluoroethoxy)phenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide

실험 절차

Using N-((2S)-1-((2-(4-(benzyloxy)-2-(2,2,2-trifluoroethoxy)phenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide and (bromomethyl)cyclopropane, and in the same manner as in Step D of Example 68, the title compound was obtained.

출처 및 근거

ORD 기록: ord-3602c4a44b7c4f92997cab30ae81a812
출처 데이터셋: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09133129B2

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