Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thionyl Chloride → 7-(Benzyloxy)-4-chloro-6-methoxyquinazoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 7-Benzyloxy-6-methoxy-3H-quinazolin-4-one | HCID 135404718 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 7-(Benzyloxy)-4-chloro-6-methoxyquinazoline | HCID 10661998 | — |
반응 단계
A mixture of 7-benzyloxy-6-methoxy-3,4-dihydroquinazolin-4-one (35 g), thionyl chloride (440 ml) and DMF (1.75 ml) was heated to reflux for 4 hours. The thionyl chloride was evaporated under vacuum and the residue was azeotroped with toluene three times. The residue was dissolved in N-methylpyrrolidin-2-one (250 ml) to give a solution of 7-benzyloxy-4-chloro-6-methoxyquinazoline.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06849625B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-b4c03b330592499e868eec12a39db24a |
| 출처 메모 | uspto-grants-2005_02 |