反应详情

A mixture of 7-benzyloxy-6-methoxy-3,4-dihydroquinazolin-4-one (35 g), thionyl chloride (440 ml) and DMF (1.75 ml) was heated to reflux for 4 hours. The thionyl chloride was evaporated under vacuum and the residue was azeotroped with toluene three times. The residue was dissolved in N-methylpyrrolidin-2-one (250 ml) to give a solution of 7-benzyloxy-4-chloro-6-methoxyquinazoline.

1. temperaturewas heated
2. temperatureto reflux for 4 hours
3. customThe thionyl chloride was evaporated under vacuum
4. customthe residue was azeotroped with toluene three times
5. dissolutionThe residue was dissolved in N-methylpyrrolidin-2-one (250 ml)