1-Bromo-3-chloropropane → 4-(3-Chloropropyl)morpholine

HRID 22775

반응식

HRID 22775 반응식
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Br[CH2:8][CH2:9][CH2:10][Cl:11]>C1(C)C=CC=CC=1>[O:4]1[CH2:5][CH2:6][N:1]([CH2:8][CH2:9][CH2:10][Cl:11])[CH2:2][CH2:3]1

참가 물질

4

반응물 2

HCID 80061-Bromo-3-chloropropaneHCID 8083Morpholine

생성물 1

HCID 958344-(3-Chloropropyl)morpholine

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
70 °C

실험 절차

A mixture of morpholine (52.2 ml), 1-bromo-3-chloropropane (30 ml) and toluene (180 ml) was heated to 70° C. for 3 hours. The solid was removed by filtration and the filtrate was evaporated under vacuum. The resultant oil was decanted from the additional solid which was deposited and the oil was purified by vacuum distillation to yield 3-morpholinopropyl chloride (37.91 g); NMR Spectrum: (DMSOd6) 1.85 (m, 2H), 2.3 (t, 4H), 2.38 (t, 2H), 3.53 (t, 4H), 3.65 (t, 2H).

후처리

  1. customThe solid was removed by filtration
  2. customthe filtrate was evaporated under vacuum
  3. customThe resultant oil was decanted from the additional solid which
  4. distillationthe oil was purified by vacuum distillation

출처 및 근거

ORD 기록
ord-a049d93aa79344ffb2fda0463cf54c65
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06849625B2

연결된 노트

불러오는 중…