3-Chloro-2-fluorobenzaldehyde → 3-Chloro-2-fluorobenzyl alcohol

HRID 2277575노트

반응식

HRID 2277575 반응식
[F:1][C:2]1[C:9]([Cl:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].[BH4-].[Na+]>C1COCC1.C(Cl)Cl>[Cl:10][C:9]1[C:2]([F:1])=[C:3]([CH2:4][OH:5])[CH:6]=[CH:7][CH:8]=1

참가 물질

5

반응물 2

HCID 7363353-Chloro-2-fluorobenzaldehydeHCID 4311764Sodium borohydride

생성물 1

HCID 27736063-Chloro-2-fluorobenzyl alcohol

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 2-fluoro-3-chloro-benzaldehyde (4.74 g, 30 mmol) in THF (20 mL) was added NaBH4 (1.48 g, 40 mmol). The resulting mixture was stirred at room temperature for 30 min before diluting with DCM. The organic layer was washed with water and brine. The combined organic layers were dried over anhy. Na2SO4, filtered and concentrated in vacuo to give desired product without further purification (4.8 g, 100%). MS: 161.0 (M+H)+.

후처리

  1. washThe organic layer was washed with water and brine
  2. customThe combined organic layers were dried over anhy
  3. filtrationNa2SO4, filtered
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-eee0d38234e948a18495c89494babee2
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09133158B2

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