Phosphorus tribromide → 1-(Bromomethyl)-3-chloro-2-fluorobenzene

HRID 2277576노트

반응식

HRID 2277576 반응식
[Cl:1][C:2]1[C:3]([F:10])=[C:4]([CH2:8]O)[CH:5]=[CH:6][CH:7]=1.P(Br)(Br)[Br:12]>C(Cl)Cl>[Br:12][CH2:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[C:3]=1[F:10]

참가 물질

4

반응물 2

HCID 24614Phosphorus tribromideHCID 27736063-Chloro-2-fluorobenzyl alcohol

생성물 1

HCID 5228271-(Bromomethyl)-3-chloro-2-fluorobenzene

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of (3-chloro-2-fluoro-phenyl)-methanol (3.2 g, 20 mmol) in DCM (20 mL) was added dropwise PBr3 (1 mL) at 0° C. The reaction mixture was stirred at room temperature for another 1 hour before quenching with satd. aq. NaHCO3 solution. The organic layer was washed with brine, dried over anhy. Na2SO4, filtered and concentrated in vacuo to give the desired product without further purification (4.1 g, 92%). MS: 223.2 (M+H)+.

후처리

  1. custombefore quenching with satd
  2. washThe organic layer was washed with brine
  3. customdried over anhy
  4. filtrationNa2SO4, filtered
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-83f5b1b3b60342609dee565456a80b17
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09133158B2

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