Sodium Hydroxide → Sodium (5-fluoro-4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetate

HRID 2278484노트

반응식

HRID 2278484 반응식
[OH-].[Na+:2].C([O:5][C:6](=[O:22])[CH2:7][C:8]1[NH:9][C:10](=[O:21])[C:11]([F:20])=[C:12]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[N:13]=1)C>C1COCC1>[F:20][C:11]1[C:10](=[O:21])[NH:9][C:8]([CH2:7][C:6]([O-:22])=[O:5])=[N:13][C:12]=1[N:14]1[CH2:15][CH2:16][O:17][CH2:18][CH2:19]1.[Na+:2]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 136069587(5-Fluoro-4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetic acid ethyl ester

생성물 1

HCID 136069585Sodium (5-fluoro-4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

2.9 ml of 2N sodium hydroxide are added to a solution of 800 mg of (5-fluoro-4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetic acid ethyl ester in 10 ml of THF. The reaction medium is stirred at ambient temperature for 24 hours. The reaction medium is concentrated under reduced pressure. The residue obtained is oven-dried under vacuum in the presence of P2O5, so as to give 780 mg of sodium (5-fluoro-4-morpholin-4-yl-6-oxo-1,6-dihydropyrimidin-2-yl)acetate, the characteristics of which are the following:

후처리

  1. concentrationThe reaction medium is concentrated under reduced pressure
  2. customThe residue obtained
  3. dry with materialis oven-dried under vacuum in the presence of P2O5

출처 및 근거

ORD 기록
ord-17a1a48e606046b1b5bd6e5dd52908e4
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09133168B2

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