Sodium Bicarbonate → HCID 72698802, 화합물

HRID 2278594노트

반응식

HRID 2278594 반응식
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[C:4]([CH3:15])([CH3:14])[CH2:5][N:6]2C(=O)C.C(=O)(O)[O-].[Na+]>Cl>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[C:4]([CH3:15])([CH3:14])[CH2:5][NH:6]2

참가 물질

4

반응물 2

HCID 516892Sodium BicarbonateHCID 68281577HCID 68281577, 화합물

생성물 1

HCID 72698802HCID 72698802, 화합물수율 72.4%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A solution of 520 mg of 1-(4-fluoro-3,3-dimethyl-2,3-dihydroindol-1-yl)ethanone in 10 ml of concentrated hydrochloric acid is heated at 90° C. for 2 hours. The solution is then treated with sodium bicarbonate until the pH is 7, and extracted with dichloromethane. The organic phase is filtered on a phase-separation column and concentrated under reduced pressure, so as to give 300 mg of 4-fluoro-3,3-dimethyl-2,3-dihydro-1H-indole in the form of a brown oil, the characteristics of which are the following:

후처리

  1. extractionextracted with dichloromethane
  2. filtrationThe organic phase is filtered on a phase-separation column
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-d93c21836d9140678230c8319f386044
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09133168B2

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