Tributylphosphine → methyl 2-((4S,5S)-1-(4-(((3R,4R)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)phenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetate

반응식

[Cl:1][C:2]1[C:3]([N:10]2[CH2:15][CH2:14][C@@H:13]([O:16][C:17]3[CH:22]=[CH:21][C:20]([N:23]4[C@@H:27]([CH2:28][C:29]([O-:31])=[O:30])[C@H:26]([CH3:32])[C:25]([C:33]([F:36])([F:35])[F:34])=[N:24]4)=[CH:19][CH:18]=3)[C@H:12]([CH3:37])[CH2:11]2)=[CH:4][C:5]([O:8][CH3:9])=[N:6][CH:7]=1.O[C:39]1C=CC(N2[C@@H](CC(OC)=O)[C@H](C)C(C(F)(F)F)=N2)=CC=1.ClC1C(N2CC[C@H](O)[C@H](C)C2)=CC(OC)=NC=1.C(P(CCCC)CCCC)CCC.N(/C(N1CCCCC1)=O)=N\C(N1CCCCC1)=O>C1(C)C=CC=CC=1>[Cl:1][C:2]1[C:3]([N:10]2[CH2:15][CH2:14][C@@H:13]([O:16][C:17]3[CH:18]=[CH:19][C:20]([N:23]4[C@@H:27]([CH2:28][C:29]([O:31][CH3:39])=[O:30])[C@H:26]([CH3:32])[C:25]([C:33]([F:36])([F:34])[F:35])=[N:24]4)=[CH:21][CH:22]=3)[C@H:12]([CH3:37])[CH2:11]2)=[CH:4][C:5]([O:8][CH3:9])=[N:6][CH:7]=1