Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → (2-Methylpyrimidin-5-yl)methanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | 2-Methylpyrimidine-5-carbaldehyde | HCID 3160970 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 생성물 | (2-Methylpyrimidin-5-yl)methanol | HCID 14686706 | — |
반응 단계
A solution of 2-methylpyrimidine-5-carbaldehyde (7.5 g, 0.058 mol) in methanol (370 mL, 9.1 mol) was cooled to 0° C. and treated with sodium tetrahydroborate (3.4 g, 0.090 mol). After 30 min, the reaction was quenched with eq H2O (200 mL) and extracted with ethyl acetate. The organic layer was dried over MgSO4 and concentrated to give the title compound as a yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09133122B2 |
| 출처 데이터셋 | uspto-grants-2015_09 |
| ORD ID | ord-de2a0261964e47fdbe979956c4b1a68e |
| 출처 메모 | uspto-grants-2015_09 |