Lithium Hydroxide → 2'-Fluoro-5-(5-methylpyridin-2-yl)-6'-(trifluoromethyl)biphenyl-3-carboxylic acid

HRID 2278762노트

반응식

HRID 2278762 반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]([F:11])([F:10])[F:9])[C:3]=1[C:12]1[CH:17]=[C:16]([C:18]2[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][N:19]=2)[CH:15]=[C:14]([C:25]([O:27]C)=[O:26])[CH:13]=1.O1CCCC1.[OH-].[Li+]>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]([F:9])([F:11])[F:10])[C:3]=1[C:12]1[CH:17]=[C:16]([C:18]2[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][N:19]=2)[CH:15]=[C:14]([C:25]([OH:27])=[O:26])[CH:13]=1

참가 물질

4

반응물 3

HCID 3939Lithium HydroxideHCID 8028TetrahydrofuranHCID 67303854Methyl 2'-fluoro-5-(5-methylpyridin-2-yl)-6'-(trifluoromethyl)biphenyl-3-carboxylate

생성물 1

HCID 673043082'-Fluoro-5-(5-methylpyridin-2-yl)-6'-(trifluoromethyl)biphenyl-3-carboxylic acid

반응 조건

온도
50 °C

실험 절차

A round bottom flask was charged with methyl 2′-fluoro-5-(5-methylpyridin-2-yl)-6′-(trifluoromethyl)biphenyl-3-carboxylate (200.00 mg, 0.51368 mmol), Tetrahydrofuran (7.8 mL, 97 mmol) and Lithium hydroxide (36.906 mg, 1.5410 mmol) and the reaction stirred at room temperature over night and at 50° C. for two days. The reaction mixture was filtered over Sodium sulfate and the solvent removed under reduced pressure to get the acid as brown solid.

후처리

  1. filtrationThe reaction mixture was filtered over Sodium sulfate
  2. customthe solvent removed under reduced pressure

출처 및 근거

ORD 기록
ord-69c1773f34a748e49a32d17f307e9039
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09133122B2

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