Sodium hydride → 1-Cyclopropylimidazolidin-2-one
반응식
Cl[CH2:2][CH2:3][NH:4][C:5]([NH:7][CH:8]1[CH2:10][CH2:9]1)=[O:6].[H-].[Na+]>C1COCC1>[CH:8]1([N:7]2[CH2:2][CH2:3][NH:4][C:5]2=[O:6])[CH2:10][CH2:9]1참가 물질
4
실험 절차
A 0° C. solution of 1-(2-chloroethyl)-3-cyclopropylurea (1.31 g, 8.06 mmol) in THF (40 mL) was treated with NaH (60% in mineral oil, 0.387 g, 9.67 mmol), stirred for 10 minutes, then warmed to RT and stirred for 6 h. The mixture was treated with satd. NH4Cl, the solids removed via filtration and washed with EtOAc. The filtrate was washed with brine, dried over Na2SO4 and concentrated to dryness to afford crude 1-cyclopropylimidazolidin-2-one (760 mg, 75%) which was used without further purification.
후처리
- stirringstirred for 6 h
- additionThe mixture was treated with satd
- customNH4Cl, the solids removed via filtration
- washwashed with EtOAc
- washThe filtrate was washed with brine
- dry with materialdried over Na2SO4
- concentrationconcentrated to dryness
출처 및 근거
- ORD 기록
- ord-b946a33d4cab406c8fa47952e3118f1f
- 출처 데이터셋
- uspto-grants-2015_09
- 특허 번호
- US09133183B2
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